Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells

Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells

Abstract Background Germacrone is an anti-inflammatory ingredient in the Chinese medicine zedoary turmeric. The purpose of this study was to explore the protective mechanism of germacrone against PC12 cells injury caused by oxygen-glucose deprivation/reperfusion (OGD/R). Methods OGD/R injury model o...

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Bibliographic Details
Main Authors: Jianxing Zhang, Li Yuan, Sujie Wang, Jiang Liu, Huiqin Bi, Guojuan Chen, Jingjing Li, Lili Chen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Complementary Medicine and Therapies
Subjects:
PC12 cells
Oxygen-glucose deprivation/reperfusion
Germacrone
Autophagy
PI3K III/Beclin-1/Bcl-2
PI3K I/Akt/mTOR
Online Access:http://link.springer.com/article/10.1186/s12906-020-2865-1

Internet

http://link.springer.com/article/10.1186/s12906-020-2865-1

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