MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation.

MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation.

Our previous studies have demonstrated that genetic deletion of the Muc2 gene causes colorectal cancers in mice. The current study further showed that at the early stage (<3 months) the Muc2 knockout mice spontaneously developed chronic inflammation in colon and rectum, similar pathological featu...

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Bibliographic Details
Main Authors: Yonghua Bao, Yongchen Guo, Zexin Li, Wenfeng Fang, Yiqiong Yang, Xuhan Li, Zhuangzhuang Li, Bowen Xiong, Zhiguo Chen, Jianguo Wang, Kang Kang, Deming Gou, Wancai Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4062425?pdf=render

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http://europepmc.org/articles/PMC4062425?pdf=render

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