The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immuno...

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Bibliographic Details
Main Authors: Paola Di Meglio, Antonella Di Cesare, Ute Laggner, Chung-Ching Chu, Luca Napolitano, Federica Villanova, Isabella Tosi, Francesca Capon, Richard C Trembath, Ketty Peris, Frank O Nestle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3043090?pdf=render

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http://europepmc.org/articles/PMC3043090?pdf=render

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