A comprehensive analysis of NPHS1 gene mutations in patients with sporadic focal segmental glomerulosclerosis

A comprehensive analysis of NPHS1 gene mutations in patients with sporadic focal segmental glomerulosclerosis

Abstract Background Focal segmental glomerulosclerosis (FSGS) is still one of the common causes of refractory nephrotic syndrome. Nephrin, encoded by podocyte-specific NPHS1 gene, participated in the pathogenesis of FSGS. The sites of NPHS1 mutations in FSGS is not clarified very well. In this study...

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Bibliographic Details
Main Authors: Ling Zhuo, Lulin Huang, Zhenglin Yang, Guisen Li, Li Wang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Medical Genetics
Subjects:
Focal segmental glomerulosclerosis
NPHS1
Mutation
Second-generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12881-019-0845-4

Internet

http://link.springer.com/article/10.1186/s12881-019-0845-4

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