Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite

Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite

Plasmodium vivax is the most common species that cause malaria outside of the African continent. The development of an efficacious vaccine would contribute greatly to control malaria. Recently, using bacterial and adenoviral recombinant proteins based on the P. vivax circumsporozoite protein (CSP),...

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Bibliographic Details
Main Authors: Alba Marina Gimenez, Luciana Chagas Lima, Katia Sanches Françoso, Priscila M. A. Denapoli, Raquel Panatieri, Daniel Y. Bargieri, Jean-Michel Thiberge, Chiara Andolina, Francois Nosten, Laurent Renia, Ruth S. Nussenzweig, Victor Nussenzweig, Rogerio Amino, Mauricio M. Rodrigues, Irene S. Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium vivax
recombinant vaccine
circumsporozoite protein
prime-boost regimens
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01275/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01275/full

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