The dysregulated expression and functional effect of CaMK2 in cancer
Abstract CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca2+ signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. Ho...
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Online Access: | https://doi.org/10.1186/s12935-021-02030-7 |
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doaj-6dc3d60375734ddbab8c6da56005dbf82021-07-04T11:48:40ZengBMCCancer Cell International1475-28672021-06-0121111510.1186/s12935-021-02030-7The dysregulated expression and functional effect of CaMK2 in cancerQi He0Zhenyu Li1College of Laboratory Medicine, Chongqing Medical UniversityDepartment of Pathology, Chongqing University Cancer HospitalAbstract CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca2+ signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment.https://doi.org/10.1186/s12935-021-02030-7CaMK2CancerProliferationMetastasisStemnessResistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi He Zhenyu Li |
spellingShingle |
Qi He Zhenyu Li The dysregulated expression and functional effect of CaMK2 in cancer Cancer Cell International CaMK2 Cancer Proliferation Metastasis Stemness Resistance |
author_facet |
Qi He Zhenyu Li |
author_sort |
Qi He |
title |
The dysregulated expression and functional effect of CaMK2 in cancer |
title_short |
The dysregulated expression and functional effect of CaMK2 in cancer |
title_full |
The dysregulated expression and functional effect of CaMK2 in cancer |
title_fullStr |
The dysregulated expression and functional effect of CaMK2 in cancer |
title_full_unstemmed |
The dysregulated expression and functional effect of CaMK2 in cancer |
title_sort |
dysregulated expression and functional effect of camk2 in cancer |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2021-06-01 |
description |
Abstract CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca2+ signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment. |
topic |
CaMK2 Cancer Proliferation Metastasis Stemness Resistance |
url |
https://doi.org/10.1186/s12935-021-02030-7 |
work_keys_str_mv |
AT qihe thedysregulatedexpressionandfunctionaleffectofcamk2incancer AT zhenyuli thedysregulatedexpressionandfunctionaleffectofcamk2incancer AT qihe dysregulatedexpressionandfunctionaleffectofcamk2incancer AT zhenyuli dysregulatedexpressionandfunctionaleffectofcamk2incancer |
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