Exploratory analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients receiving neo-adjuvant chemotherapy for operable breast cancer

Exploratory analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients receiving neo-adjuvant chemotherapy for operable breast cancer

Abstract Background While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun testing in patients with breast cancer (BC), the effects of chemotherapy on ICP expression in circulating T cells and within the tumor microenvironment are still unclear. This...

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Bibliographic Details
Main Authors: Robert Wesolowski, Andrew Stiff, Dionisia Quiroga, Christopher McQuinn, Zaibo Li, Hiroaki Nitta, Himanshu Savardekar, Brooke Benner, Bhuvaneswari Ramaswamy, Maryam Lustberg, Rachel M. Layman, Erin Macrae, Mahmoud Kassem, Nicole Williams, Sagar Sardesai, Jeffrey VanDeusen, Daniel Stover, Mathew Cherian, Thomas A. Mace, Lianbo Yu, Megan Duggan, William E. Carson
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Breast cancer
Tumor-infiltrating lymphocytes
CD8+ T cells
Immune checkpoint receptors
Online Access:http://link.springer.com/article/10.1186/s12885-020-06949-4

Internet

http://link.springer.com/article/10.1186/s12885-020-06949-4

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