Osteoporosis in Skin Diseases
Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most...
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doaj-73ddf1aa3ace4f5fb3cae2226b0926e92020-11-25T02:38:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01214749474910.3390/ijms21134749Osteoporosis in Skin DiseasesMaria Maddalena Sirufo0Francesca De Pietro1Enrica Maria Bassino2Lia Ginaldi3Massimo De Martinis4Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyOsteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.https://www.mdpi.com/1422-0067/21/13/4749osteoporosisdermatologyskinskin diseasesboneskeletal health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Maddalena Sirufo Francesca De Pietro Enrica Maria Bassino Lia Ginaldi Massimo De Martinis |
spellingShingle |
Maria Maddalena Sirufo Francesca De Pietro Enrica Maria Bassino Lia Ginaldi Massimo De Martinis Osteoporosis in Skin Diseases International Journal of Molecular Sciences osteoporosis dermatology skin skin diseases bone skeletal health |
author_facet |
Maria Maddalena Sirufo Francesca De Pietro Enrica Maria Bassino Lia Ginaldi Massimo De Martinis |
author_sort |
Maria Maddalena Sirufo |
title |
Osteoporosis in Skin Diseases |
title_short |
Osteoporosis in Skin Diseases |
title_full |
Osteoporosis in Skin Diseases |
title_fullStr |
Osteoporosis in Skin Diseases |
title_full_unstemmed |
Osteoporosis in Skin Diseases |
title_sort |
osteoporosis in skin diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-07-01 |
description |
Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice. |
topic |
osteoporosis dermatology skin skin diseases bone skeletal health |
url |
https://www.mdpi.com/1422-0067/21/13/4749 |
work_keys_str_mv |
AT mariamaddalenasirufo osteoporosisinskindiseases AT francescadepietro osteoporosisinskindiseases AT enricamariabassino osteoporosisinskindiseases AT liaginaldi osteoporosisinskindiseases AT massimodemartinis osteoporosisinskindiseases |
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1724792380132950016 |