Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Abstract Background Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading to abnormal expression of different genes as important regulators of di...

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Bibliographic Details
Main Authors: Kashif Rafiq Zahid, Mingyang Su, Abdur Rehman Raza Khan, Shiming Han, Gou Deming, Umar Raza
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
Systems biology
miRNA–mRNA regulatory network
Hepatocellular carcinoma
Tumor progression
Metabolic pathways
Cell cycle signaling
Online Access:http://link.springer.com/article/10.1186/s12935-019-0804-3

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http://link.springer.com/article/10.1186/s12935-019-0804-3

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