Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the...

Full description

Bibliographic Details
Main Authors: Tina Schumann, Jörg König, Christian von Loeffelholz, Daniel F. Vatner, Dongyan Zhang, Rachel J. Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N. El-Agroudy, Diana M. Willmes, Dominik Pesta, Rafael de Cabo, John F. O´Sullivan, Eric Simon, Gerald I. Shulman, Bradford S. Hamilton, Andreas L. Birkenfeld
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02279-8

Internet

https://doi.org/10.1038/s42003-021-02279-8

Similar Items