Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

The canonical action of the p85α regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is to associate with the p110α catalytic subunit to allow stimuli-dependent activation of the PI3K pathway. We elucidate a p110α-independent role of homodimerized p85α in the positive regulation of PTEN stabi...

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Bibliographic Details
Main Authors: Lydia WT Cheung, Katarzyna W Walkiewicz, Tabot MD Besong, Huifang Guo, David H Hawke, Stefan T Arold, Gordon B Mills
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
PI3K
mutation
PTEN
cancer
p85
Online Access:https://elifesciences.org/articles/06866

Internet

https://elifesciences.org/articles/06866

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