shRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines

shRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines

Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine (GalNAc) degradation of ECM components by α-N-acetylgalactosaminidase (Nagalase) which facilitates migration...

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Bibliographic Details
Main Authors: Ehsan Saburi, Jalil Tavakolafshari, Yousef Mortazavi, Alireza Biglari, Seyed Abbas Mirzaei, Samad Nadri
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-09-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Alpha-N-Acetylgalactosamini dase
Cancer
Extracellular matrix
Invasion
Migration
shRNA
Online Access:http://ijbms.mums.ac.ir/article_9271_452a27516d93e28ba9d3c97acf8e767c.pdf

Internet

http://ijbms.mums.ac.ir/article_9271_452a27516d93e28ba9d3c97acf8e767c.pdf

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