Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish

Abstract Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is...

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Bibliographic Details
Main Authors: Xing Wang, Shabnam Salimi, Zhongliang Deng, James Perry, Kathleen A. Ryan, Zhizhen Li, Dongfang Liu, Elizabeth Streeten, Alan R. Shuldiner, Mao Fu
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25272-4