Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.

Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.

Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin endocytosis plays an important role in the development of TII. Some reports have shown protective effects of lithium on kidney injury animal mode...

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Bibliographic Details
Main Authors: Douglas E Teixeira, Diogo B Peruchetti, Leandro S Silva, Rodrigo P Silva-Aguiar, Morgana B Oquendo, João Luiz Silva-Filho, Christina M Takiya, José Henrique Leal-Cardoso, Ana Acacia S Pinheiro, Celso Caruso-Neves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215871

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https://doi.org/10.1371/journal.pone.0215871

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