In vitro Inactivation of Rat Brain Acetylcholinesterase by DSP-4 and Its Derivatives OS-21 and OS-23 and Protective Activity of Tacrine (9-Amino-1,2,3,4-tetrahydroacridine)
Tertiary N-haloethylamines are able to cyclize to the corresponding aziridinium ions. The inhibitory activity of the DSP-4 (N-(o-brombenzyl)-N-ethyl-2-chlorethylamine) and its two derivatives OS-21 (N-benzyl-N-ethyl-2-chloroethylamine) and OS-23 (N-fenylethyl-N-ethyl-2-chloroethylamine) was studied...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2005-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/48/3/0145/ |