Mendelian randomization for studying the effects of perturbing drug targets [version 2; peer review: 2 approved, 1 approved with reservations]
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer i...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wellcome
2021-02-01
|
Series: | Wellcome Open Research |
Online Access: | https://wellcomeopenresearch.org/articles/6-16/v2 |