Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important intracellular antioxidant that protects neurons from reactive oxygen species. We hypothesized that levels of GSH measured by MR spec...

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Bibliographic Details
Main Authors: Ovidiu C. Andronesi, Katharine Nicholson, Kourosh Jafari-Khouzani, Wolfgang Bogner, Jing Wang, James Chan, Eric A. Macklin, Mark Levine-Weinberg, Christopher Breen, Michael A. Schwarzschild, Merit Cudkowicz, Bruce R. Rosen, Sabrina Paganoni, Eva-Maria Ratai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neurology
Subjects:
magnetic resonance spectroscopic imaging (MRSI)
neurochemistry
glutathione (GSH)
neurodegeneration
T1 relaxation in the rotating frame (T1rho)
macromolecular fraction
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.590573/full

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https://www.frontiersin.org/articles/10.3389/fneur.2020.590573/full

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