Compromised Biomechanical Properties, Cell–Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation

Compromised Biomechanical Properties, Cell–Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation

Clinical effects induced by arrhythmogenic cardiomyopathy (ACM) originate from a large spectrum of genetic variations, including the missense mutation of the lamin A/C gene (<i>LMNA</i>), <i>LMNA</i> D192G. The aim of our study was to investigate the biophysical and biomechan...

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Bibliographic Details
Main Authors: Veronique Lachaize, Brisa Peña, Catalin Ciubotaru, Dan Cojoc, Suet Nee Chen, Matthew R. G. Taylor, Luisa Mestroni, Orfeo Sbaizero
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
arrhythmogenic cardiomyopathy (ACM)
lamin A/C
atomic force microscopy (AFM)
cell–cell adhesion
neonatal rat ventricular fibroblasts (NRVF)
tunneling nanotubes (TNT)
Online Access:https://www.mdpi.com/1422-0067/22/17/9193

Internet

https://www.mdpi.com/1422-0067/22/17/9193

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