Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids

We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids. A number of these compounds displayed enhanced activity against Gram-positive and Gram-negative bacteria when compared to c...

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Bibliographic Details
Main Authors: Tomasz Plech, Barbara Kaproń, Agata Paneth, Urszula Kosikowska, Anna Malm, Aleksandra Strzelczyk, Paweł Stączek, Łukasz Świątek, Barbara Rajtar, Małgorzata Polz-Dacewicz
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
fluoroquinolones
gyrase DNA
topoisomerase IV
topoisomerase inhibitors
MTT assay
Online Access:http://www.mdpi.com/1420-3049/20/4/6254

Internet

http://www.mdpi.com/1420-3049/20/4/6254

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