BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase.

BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase.

BMS309403 is a biphenyl azole inhibitor against fatty acid binding protein 4 (FABP4) and regarded as a lead compound for effective treatment of obesity related cardio-metabolic diseases. Here we discovered an off-target activity of BMS309403 in that it stimulates glucose uptake in C2C12 myotubes in...

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Bibliographic Details
Main Authors: Wanhua Lin, Xiaoli Huang, Lina Zhang, Dongmei Chen, Dongye Wang, Qilong Peng, Lei Xu, Jingya Li, Xiujie Liu, Kuai Li, Ke Ding, Shouguang Jin, Jia Li, Donghai Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3432117?pdf=render

Internet

http://europepmc.org/articles/PMC3432117?pdf=render

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