Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease

NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘)ii The prime symbol (`) is used to distinguish between NS4A residues and NS3 residues of (no prime). are essential for...

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Bibliographic Details
Main Authors: Moustafa E. El-Araby, Abdelsattar M. Omar, Sameh H. Soror, Stefan T. Arold, Maan T. Khayat, Hani Z. Asfour, Faida Bamane, Mahmoud A. Elfaky
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Advanced Research
Subjects:
DSLS
Fluorescence anisotropy
Allosteric inhibitor
HCV
NS3/4A
Peptide mutants
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220300035

Internet

http://www.sciencedirect.com/science/article/pii/S2090123220300035

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