Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel

Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel

Abstract Background Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a germline-related BRCA1 mutated MANEC of his ileum. The tumor presented a...

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Bibliographic Details
Main Authors: A. Quaas, D. Waldschmidt, H. Alakus, T. Zander, C. Heydt, T. Goeser, M. Daheim, P. Kasper, P. Plum, C. Bruns, A. Brunn, W. Roth, N. Hartmann, A. Bunck, M. Schmidt, H. Göbel, L. Tharun, R. Buettner, S. Merkelbach-Bruse
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Gastroenterology
Subjects:
Small bowel mixed adeno-neuroendocrine carcinoma (MANEC)
BRCA1 mutation
Germline-related
PARP-inhibition
Personalized treatment
Online Access:http://link.springer.com/article/10.1186/s12876-018-0803-1

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http://link.springer.com/article/10.1186/s12876-018-0803-1

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