Formation of toxic oligomeric alpha-synuclein species in living cells.

Formation of toxic oligomeric alpha-synuclein species in living cells.

Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders. Although fibrillar alpha-synuclein is a major component of Lewy bodies (LBs), recent data implicate prefibrillar, o...

Full description

Bibliographic Details
Main Authors: Tiago Fleming Outeiro, Preeti Putcha, Julie E Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T Hyman, Pamela J McLean
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2270899?pdf=render

Internet

http://europepmc.org/articles/PMC2270899?pdf=render

Similar Items