Angioedema: Perioperative management

• Main Authors: Andrew A Maynard, Christina F Burger, Joseph J Schlesinger
• Format: Article
• Language: English
• Published: SAGE Publishing 2017-06-01
• Series: SAGE Open Medical Case Reports
• Online Access: https://doi.org/10.1177/2050313X17713912

Objective: To describe the perioperative management of a patient with acquired angioedema (AAE). Methods: A 66-year-old Caucasian male presented from an outside hospital with a history of acquired angioedema and gastrointestinal stromal tumor–related intractable urticaria and mastocytosis. He was admitted for urgent laparoscopic partial gastrectomy, secondary to gastric outlet obstruction symptomatology. Previous combined attacks were characterized by a widespread rash, abdominal pain and respiratory distress resulting in hospitalization. Following preoperative consultation with the patient’s allergist and a hospital pharmacist, he was treated preoperatively with fresh frozen plasma and his home prednisone dose. C1-inhibitor (Berinert®) was on standby along with epinephrine, given that the underlying etiology (C1- inhibitor deficiency vs histaminergic) was not known. Results: There were no intraoperative complications, and the patient was discharged home 3 days after the procedure. Conclusions: Optimization of perioperative outcomes in patients, especially during urgent or emergent surgery, with a history of angioedema requires the development of a patient-specific perioperative plan, including prophylaxis, rescue therapies and opioid-sparing strategies.