Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis

Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis

Summary: Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results in slow tumorigenesis. As a regulator of the Hippo signaling pathway, NF2 induces LATS1/2 kinases and consequently represses YAP/TAZ. YAP/TAZ...

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Bibliographic Details
Main Authors: Yu Wang, Yuwen Zhu, Yuan Gu, Mingyue Ma, Yebin Wang, Sixian Qi, Yan Zeng, Rui Zhu, Xueying Wang, Pengcheng Yu, Jianhui Xu, Yilai Shu, Fa-Xing Yu
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
NF2
YAP
Hippo signaling
RNF146
TNKS1/2
neurofibromatosis type 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010342

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http://www.sciencedirect.com/science/article/pii/S2211124721010342

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