Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies

Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies

Pathogenesis of Staphylococcus aureus is increasingly recognized to be driven by powerful toxins. Staphylococcus aureus employs up to six pore-forming toxins to subvert the human host defense and to promote bacterial invasion: alpha-hemolysin that disrupts epithelial and endothelial barriers and fiv...

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Bibliographic Details
Main Authors: Harald Rouha, Susanne Weber, Philipp Janesch, Barbara Maierhofer, Karin Gross, Ivana Dolezilkova, Irina Mirkina, Zehra C. Visram, Stefan Malafa, Lukas Stulik, Adriana Badarau, Eszter Nagy
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Staphylococcus aureus
leukocidins
alpha-hemolysin
toxin neutralization
human monoclonal antibodies
host defense
Online Access:http://dx.doi.org/10.1080/21505594.2017.1391447

Internet

http://dx.doi.org/10.1080/21505594.2017.1391447

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