Tocilizumab for the Treatment of Mevalonate Kinase Deficiency

Mevalonate kinase deficiency (MKD) is a severe autoinflammatory disease caused by recessive mutations in MVK resulting in reduced function of the enzyme mevalonate kinase, involved in the cholesterol/isoprenoid pathway. MKD presents with periodic episodes of severe systemic inflammation, poor qualit...

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Bibliographic Details
Main Authors: Nadia K. Rafiq, Helen Lachmann, Frodi Joensen, Troels Herlin, Paul A. Brogan
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2018/3514645