Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

Roles of the renin-angiotensin system in autophagy and ischemia/reperfusion (I/R) injury in the kidney have not been fully characterized. Here we examined the hypothesis that modest activation of the angiotensin II (Ang II) receptor upregulates autophagy and increases renal tolerance to I/R injury....

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Bibliographic Details
Main Authors: Hirohito Sugawara, Norihito Moniwa, Atsushi Kuno, Wataru Ohwada, Arata Osanami, Satoru Shibata, Yukishige Kimura, Koki Abe, Yufu Gocho, Masaya Tanno, Tetsuji Miura
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Acute kidney injury
AT1 receptor
Autophagy
Ischemia-reperfusion injury
Mas receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320301195

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http://www.sciencedirect.com/science/article/pii/S1347861320301195

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