A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers. Many hot-spot mutations of TP53 confer novel functions not found in wild-type p53 and contribute to tumor development and progression. We report on the generation of a H1 human embryonic stem cell line carrying a ho...

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Bibliographic Details
Main Authors: Ruoji Zhou, An Xu, Donghui Wang, Dandan Zhu, Helen Mata, Zijun Huo, Jian Tu, Mo Liu, Alaa M.T. Mohamed, Brittany E. Jewell, Julian Gingold, Weiya Xia, Pulivarthi H. Rao, Mien-Chie Hung, Ruiying Zhao, Dung-Fang Lee
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118300412

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http://www.sciencedirect.com/science/article/pii/S1873506118300412

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