Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.

Bibliographic Details
Main Authors: Clint L. Miller, Milos Pjanic, Ting Wang, Trieu Nguyen, Ariella Cohain, Jonathan D. Lee, Ljubica Perisic, Ulf Hedin, Ramendra K. Kundu, Deshna Majmudar, Juyong B. Kim, Oliver Wang, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Themistocles L. Assimes, Stephen B. Montgomery, Eric E. Schadt, Johan L.M. Björkegren, Thomas Quertermous
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12092

Internet

https://doi.org/10.1038/ncomms12092

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