Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights from Molecular Dynamics Simulation of the Amphotericin B and Nystatin Interactions with Polysorbate 80

Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights from Molecular Dynamics Simulation of the Amphotericin B and Nystatin Interactions with Polysorbate 80

Amphotericin B (AmB) and Nystatin (Nys) are the drugs of choice for treatment of systemic and superficial mycotic infections, respectively, with their full clinical potential unrealized due to the lack of high therapeutic index formulations for their solubilized delivery. In the present study, using...

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Bibliographic Details
Main Authors: Meysam Mobasheri, Hossein Attar, Seyed Mehdi Rezayat Sorkhabadi, Ali Khamesipour, Mahmoud Reza Jaafari
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
polyene antibiotics
Amphotericin B
Nystatin
Polysorbate 80
solubilization
molecular dynamics simulation
drug formulation
drug delivery systems
nanomedicine
Online Access:http://www.mdpi.com/1420-3049/21/1/6

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http://www.mdpi.com/1420-3049/21/1/6

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