Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling

The Janus kinase-signal transducer and activator of transcription protein (JAK-STAT) pathway mediates essential biological functions from immune responses to haematopoiesis. Deregulated JAK-STAT signaling causes myeloproliferative neoplasms, leukaemia, and lymphomas, as well as autoimmune diseases....

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Bibliographic Details
Main Authors: Juuli Raivola, Teemu Haikarainen, Olli Silvennoinen
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
jak
Online Access:https://www.mdpi.com/2072-6694/12/1/78