m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

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Abstract Background METTL3 is an RNA methyltransferase that mediates m6A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very...

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Bibliographic Details
Main Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan, Guoming Su
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Hematology & Oncology
Subjects:
m6A Modification
METTL3
YTHDF1/3
eIF3b
MALAT1
miR-1914-3p
Online Access:https://doi.org/10.1186/s13045-019-0830-6

Internet

https://doi.org/10.1186/s13045-019-0830-6

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