Study protocol: design and rationale for an exploratory phase II randomized controlled trial to determine optimal vitamin D3 supplementation strategies for acute fracture healing

Study protocol: design and rationale for an exploratory phase II randomized controlled trial to determine optimal vitamin D3 supplementation strategies for acute fracture healing

Abstract Background Observational studies have found that 75% of healthy adult fracture patients (ages 18–50) have serum 25-hydroxyvitamin D (25(OH)D) levels < 30 ng/mL. Although lower serum 25(OH)D levels have yet to be correlated to fracture healing complications or poor fracture outcomes, many...

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Bibliographic Details
Main Authors: Sheila Sprague, Sofia Bzovsky, Daniel Connelly, Lehana Thabane, Jonathan D. Adachi, Gerard P. Slobogean, on behalf of the Vita-Shock Investigators
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Pilot and Feasibility Studies
Subjects:
Clinical protocols
Tibial shaft fractures
Femoral shaft fractures
Fracture fixation
Vitamin D
Randomized controlled trial
Online Access:http://link.springer.com/article/10.1186/s40814-019-0524-4

Internet

http://link.springer.com/article/10.1186/s40814-019-0524-4

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