Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages

Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages

Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimul...

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Bibliographic Details
Main Authors: David E. Damby, Claire J. Horwell, Peter J. Baxter, Ulrich Kueppers, Max Schnurr, Donald B. Dingwell, Peter Duewell
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
inflammasome
NLRP3
reactive oxygen species
lysosomal damage
volcanic ash
cristobalite
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.02000/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.02000/full

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