Pathologic prion protein is specifically recognized in situ by a novel PrP conformational antibody

Pathologic prion protein is specifically recognized in situ by a novel PrP conformational antibody

Prion diseases are characterized by the accumulation in the brain of abnormal conformers (PrPSc) of the cellular prion protein (PrPC).PrPSc immunohistochemistry, currently based on antibodies non-distinguishing between PrPC and PrPSc, requires pre-treatments of histological sections to eliminate PrP...

Full description

Bibliographic Details
Main Authors: Gianluca Moroncini, Michela Mangieri, Michela Morbin, Giulia Mazzoleni, Bernardino Ghetti, Armando Gabrielli, Robert Anthony Williamson, Giorgio Giaccone, Fabrizio Tagliavini
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610600146X

Internet

http://www.sciencedirect.com/science/article/pii/S096999610600146X

Similar Items