Size polymorphism and low sequence diversity in the locus encoding the Plasmodium vivax rhoptry neck protein 4 (PvRON4) in Colombian isolates

Size polymorphism and low sequence diversity in the locus encoding the Plasmodium vivax rhoptry neck protein 4 (PvRON4) in Colombian isolates

Abstract Background Designing a vaccine against Plasmodium vivax has focused on selecting antigens involved in invasion mechanisms that must have domains with low polymorphism for avoiding allele-specific immune responses. The rhoptry neck protein 4 (RON4) forms part of the tight junction, which is...

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Bibliographic Details
Main Authors: Sindy P. Buitrago, Diego Garzón-Ospina, Manuel A. Patarroyo
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Malaria Journal
Subjects:
Plasmodium vivax
Rhoptry
Genetic diversity
Tandem repeat
pvron4
Natural selection
Online Access:http://link.springer.com/article/10.1186/s12936-016-1563-4

Internet

http://link.springer.com/article/10.1186/s12936-016-1563-4

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