The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models

The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models

The purpose of this study was to create novel urate under-excretion animal models using pyrazinamide and to evaluate whether dihydropyridine calcium channel blockers (CCBs) have uricosuric effects in vivo.Adult male ICR mice were treated with pyrazinamide, vehicle (dimethyl sulfoxide: DMSO), or tap...

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Bibliographic Details
Main Authors: Takayuki Hori, Motoshi Ouchi, Naoyuki Otani, Masakatsu Nohara, Asuka Morita, Yusuke Otsuka, Promsuk Jutabha, Ikuko Shibasaki, Yasushi Matsushita, Tomoe Fujita, Hirotsugu Fukuda, Naohiko Anzai
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318300434

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http://www.sciencedirect.com/science/article/pii/S1347861318300434

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