Biophysical basis for three distinct dynamical mechanisms of action potential initiation.

Transduction of graded synaptic input into trains of all-or-none action potentials (spikes) is a crucial step in neural coding. Hodgkin identified three classes of neurons with qualitatively different analog-to-digital transduction properties. Despite widespread use of this classification scheme, a...

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Bibliographic Details
Main Authors: Steven A Prescott, Yves De Koninck, Terrence J Sejnowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2551735?pdf=render