Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP)

Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP)

Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP). XIAP is frequently overexpressed in human leukemia and prostate and breast tumors. Inhibition of a...

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Bibliographic Details
Main Authors: Maximilian A. Seiter, Stefan Salcher, Martina Rupp, Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Jérémie Mortier, Gerhard Wolber, Judith M. Rollinger, Petra Obexer, Michael J. Ausserlechner
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
XIAP inhibitor
Small-molecular weight
Cell permeable
Sanggenon G
Natural
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000655

Internet

http://www.sciencedirect.com/science/article/pii/S2211546314000655

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