NQO1 protects obese mice through improvements in glucose and lipid metabolism

NQO1 protects obese mice through improvements in glucose and lipid metabolism

Abstract Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection f...

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Bibliographic Details
Main Authors: Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A. Aon, Krystle Kalafut, Margaux R. Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J. Pearson, Sophie Levan, Joshua D. Preston, Alejandro Martin-Montalvo, Jennifer L. Martindale, Kotb Abdelmohsen, Cole R. Michel, Diana M. Willmes, Christine Henke, Placido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-020-00051-6

Internet

https://doi.org/10.1038/s41514-020-00051-6

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