Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoter...

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Bibliographic Details
Main Authors: Marbach, Daniel (Author), Lamparter, David (Author), Quon, Gerald (Contributor), Kellis, Manolis (Contributor), Kutalik, Zoltán (Author), Bergmann, Sven (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-08-31T17:40:05Z.
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