Calibrating genomic and allelic coverage bias in single-cell sequencing
Artifacts introduced in whole-genome amplification (WGA) make it difficult to derive accurate genomic information from single-cell genomes and require different analytical strategies from bulk genome analysis. Here, we describe statistical methods to quantitatively assess the amplification bias resu...
Main Authors: | , , , , , , , , |
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Other Authors: | , |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2017-10-02T14:11:45Z.
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Subjects: | |
Online Access: | Get fulltext |