Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing...

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Main Authors: Ha, Gavin (Author), Freeman, Samuel S. (Author), Choudhury, Atish D. (Author), Stover, Daniel G. (Author), Parsons, Heather A. (Author), Gydush, Gregory (Author), Reed, Sarah C. (Author), Rotem, Denisse (Author), Rhoades, Justin (Author), Livitz, Dimitri (Author), Rosebrock, Daniel (Author), Leshchiner, Ignaty (Author), Kim, Jaegil (Author), Stewart, Chip (Author), Rosenberg, Mara (Author), Francis, Joshua M. (Author), Zhang, Cheng-Zhong (Author), Cohen, Ofir (Author), Oh, Coyin (Author), Polak, Paz (Author), Lloyd, Max (Author), Mahmud, Sairah (Author), Helvie, Karla (Author), Merrill, Margaret S. (Author), Santiago, Rebecca A. (Author), O'Connor, Edward P. (Author), Jeong, Seong H. (Author), Kramkowski, Joseph F. (Author), Zhang, Zhenwei (Author), Polacek, Laura (Author), Lohr, Jens G. (Author), Schleicher, Molly (Author), Lipscomb, Emily (Author), Saltzman, Andrea (Author), Oliver, Nelly M. (Author), Marini, Lori (Author), Waks, Adrienne G. (Author), Harshman, Lauren C. (Author), Tolaney, Sara M. (Author), Van Allen, Eliezer M. (Author), Winer, Eric P. (Author), Lin, Nancy U. (Author), Nakabayashi, Mari (Author), Taplin, Mary-Ellen (Author), Johannessen, Cory M. (Author), Garraway, Levi A. (Author), Golub, Todd R. (Author), Boehm, Jesse S. (Author), Wagle, Nikhil (Author), Getz, Gad (Author), Meyerson, Matthew (Author), Adalsteinsson, Viktor A. (Contributor), Loginov, Denis (Contributor), Ding, Huiming (Contributor), Leeson, Rachel (Contributor), Barry, Rachel M (Contributor), Love, John C (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-11T20:16:51Z.
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