Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationshi...

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Main Authors: Randall, Elizabeth C. (Author), Laramy, Janice K. (Author), Kim, Minjee (Author), Roos, Alison (Author), Calligaris, David (Author), Regan, Michael S. (Author), Gupta, Shiv K. (Author), Mladek, Ann C. (Author), Carlson, Brett L. (Author), Johnson, Aaron J. (Author), Lu, Fa-Ke (Author), Xie, X. Sunney (Author), Peng, Sen (Author), Abdelmoula, Walid M. (Author), Jackson, Pamela R. (Author), Kolluri, Aarti (Author), Kellersberger, Katherine A. (Author), Agar, Jeffrey N. (Author), Swanson, Kristin R. (Author), Tran, Nhan L. (Author), Elmquist, William F. (Author), Sarkaria, Jann N. (Author), Agar, Nathalie Y. R. (Author), Emdal, Kristina Bennet (Contributor), Joughin, Brian Alan (Contributor), Reddy, Raven J. (Contributor), Lauffenburger, Douglas A (Contributor), White, Forest M. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), White, Forest M (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2019-03-22T15:22:45Z.
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