Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationshi...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Other Authors: | , , |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2019-03-22T15:22:45Z.
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Subjects: | |
Online Access: | Get fulltext |