Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Global containment of COVID-19 still requires accessible and affordable vaccines for low- and middle-income countries (LMICs). Recently approved vaccines provide needed interventions, albeit at prices that may limit their global access. Subunit vaccines based on recombinant proteins are suited for l...

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Main Authors: Dalvie, Neil C. (Author), Rodriguez-Aponte, Sergio A. (Author), Hartwell, Brittany L. (Author), Tostanoski, Lisa H. (Author), Biedermann, Andrew M. (Author), Crowell, Laura E (Author), Kaur, Kawaljit (Author), Kumru, Ozan S. (Author), Carter, Lauren (Author), Yu, Jingyou (Author), Chang, Aiquan (Author), McMahan, Katherine (Author), Courant, Thomas (Author), Lebas, Celia (Author), Lemnios, Ashley A. (Author), Rodrigues, Kristen A. (Author), Silva, Murillo (Author), Johnston, Ryan S. (Author), Naranjo, Christopher (Author), Tracey, Mary Kate (Author), Brady, Joseph R. (Author), Whittaker, Charles A. (Author), Yun, Dongsoo (Author), Brunette, Natalie (Author), Wang, Jing Yang (Author), Walkey, Carl (Author), Fiala, Brooke (Author), Kar, Swagata (Author), Porto, Maciel (Author), Lok, Megan (Author), Andersen, Hanne (Author), Lewis, Mark G. (Author), Love, Kerry R. (Author), Camp, Danielle L. (Author), Silverman, Judith Maxwell (Author), Kleanthous, Harry (Author), Joshi, Sangeeta B. (Author), Volkin, David B. (Author), Dubois, Patrice M. (Author), Collin, Nicolas (Author), King, Neil P. (Author), Barouch, Dan H. (Author), Irvine, Darrell J (Author), Love, Christopher J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2021-10-04T16:04:00Z.
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