Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation. The faithful transmission of information through two-component pathways and the...

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Main Authors: Capra, Emily Jordan (Contributor), Perchuk, Barrett (Contributor), Lubin, Emma Alexandra (Contributor), Ashenberg, Orr (Contributor), Skerker, Jeffrey M. (Author), Laub, Michael T (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Laub, Michael T. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-07-06T13:31:34Z.
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