PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited time window of efficacy, indicating a need for additional therapeutic options. Zebrafish have emerged as a powerful too...

Full description

Bibliographic Details
Main Authors: North, Trista E. (Author), Vedder, Lea M. (Author), Lord, Allegra M. (Author), Wishnok, John S. (Contributor), Tannenbaum, Steven Robert (Contributor), Zon, Leonard I. (Author), Goessling, Wolfram (Author), Badu, I. Ramesh (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-10-31T16:41:27Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items