Mutation mapping and identification by whole-genome sequencing

Mutation mapping and identification by whole-genome sequencing

Genetic mapping of mutations in model systems has facilitated the identification of genes contributing to fundamental biological processes including human diseases. However, this approach has historically required the prior characterization of informative markers. Here we report a fast and cost-effe...

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Main Authors: Leshchiner, Ignaty (Author), Alexa, Kristen (Author), Kelsey, Peter (Author), Adzhubey, Ivan (Author), Austin-Tse, Christina A. (Author), Cooney, Jeffrey D. (Author), Anderson, Heidi (Author), King, Matthew J. (Author), Stottmann, Rolf W. (Author), Garnaas, Maija K. (Author), Ha, Seungshin (Author), Drummond, Iain A. (Author), Paw, Barry H. (Author), North, Trista E. (Author), Beier, David R. (Author), Goessling, Wolfram (Contributor), Sunyaev, Shamil R. (Contributor)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2012-12-10T19:41:00Z.
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