Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation

Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation

Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions...

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Bibliographic Details
Main Authors: Soundararajan, Venkataramanan (Contributor), Patel, Neel (Contributor), Warnock, Ken (Contributor), Wilson, Ian A. (Author), Raguram, S. (Contributor), Sasisekharan, V. (Contributor), Sasisekharan, Ram (Contributor), Zheng, Shu, M. Eng. Massachusetts Institute of Technology (Author), Raman, Rahul (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Shu, Zheng (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-01-18T19:33:25Z.
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